помогите составить предложения со словами Shortcoming, winkle out substances, to be

Помогите составить предложения со словами Shortcoming, winkle out substances, to be a boom for smb., come up with, attach to, spot, to be validated by, efforts to be required, choose available components, give access to, related to method prospects, to be suited for, envision something , orthogonal methods, facilitate discovery, conduct screening, distinguish, data reveal .